Consider the US Population-Based EQ-5D (Shawn et al., 2005) table at the end for questions 1-2

1.(1.5 points) Sketch the QALY diagram and determine how many QALYs are achieved during the year by a patient in a 1-year clinical trial who has a baseline EQ-5D health state of 13322, a 6-month EQ-5D health state of 12212, and a 1-year EQ-5D health state of 11211. Assume that health states changes between measurements are smooth and gradual over time so that changes in utility scores can be approximated by a straight line.

According to the baseline EQ-5D health state table, 13322 has value (0,370), SE (0,014)

@ 6 Months 12212 has value (0,765) , SE (0.009)

@ 12 Months 11211 has value (0,880), SE (0.008)

If you send me an email I can forward the complete table, however you don't need it to solve this problem.

2.(1.5 points) Suppose the patent in question 1 was the typical patient in the treatment group, and the typical patient in the control group has a baseline EQ-5D health state of 13322, a 6-month EQ-5D health state of 13222 and a 1-year EQ-5D health state of 13222. Sketch the QALY diagram for the two patients and determine the QALYs gained over the year for the treatment patient compared to the control patient.

According to the baseline EQ-5D health state table, 13322 has value (0,370), SE (0,014)

@ 6 Months 13222 has value (0,436) , SE (0.015)

@ 12 Months 13222 has value (0,436), SE (0.015)