Question: Create a table for individual II - 2 that shows the hypothesis, prior probabilities, relevant conditional probabilities, joint probabilities, and posterior probabilities of II -
Create a table for individual II that shows the hypothesis, prior probabilities, relevant conditional probabilities, joint probabilities, and posterior probabilities of II being a carrier and noncarrier. Use the information provided above to determine appropriate prior probabilities and conditional probabilities. In your table, explicitly show the values used to calculate posterior probabilities as was done in the paper. Also clearly indicate the specific conditional probability being determined. Probabilities can be shown as fractions or decimals. Upload your table as a separate pdf file. As discussed in the paper, sometimes genetic tests are available that can help to refine the risk assessment that an unaffected person is a carrier of a disease allele. Consider the pedigree below, which shows the family inheritance pattern for an autosomal disorder with complete penetrance.
Suppose that individuals II and II are planning to have a child. IIs brother is affected by the disorder. II is unaffected and comes from a population where the overall incidence of being affected is in It is assumed that IIs population is in HardyWeinberg equilibrium for this disease allele.
A genetic test exists that detects of diseasecausing mutations in the populations that II and II belong to Both II and II tested negative for all diseasecausing mutations.
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