DNP is referred to as an electron transport chain (ETC) “decoupler,” because it uncouples the oxidation of NADH from the synthesis of ATP. In the presence of DNP, NADH is still oxidized by complex I and oxygen can be reduced, but no ATP is produced. Cyanide, a different metabolic poison, inhibits ATP production through a different mechanism - it inhibits the oxidation of complex IV by oxygen. Would you consider cyanide an ETC decoupler?

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Yes because cyanide inhibits ATP production in the mitochondria Uncouplers are the chemic... View the full answer