Do you think the organization itself can create a lot of these issues?(Resistance to change, lack of leadership commitment, inadequate communication, insufficient employee involvement) For instance, if past changes result in a workforce reduction, doesn't the following announced change immediately send shockwaves throughout members and immediately set them on the path to resist change and perhaps actively work against it?

As you note, leadership is essential, but these downsizings often affect middle management the hardest, directly impacting those responsible for communicating the positive benefits of the change to the workers. The change initiative seems to be set up for failure from the start.