Draw and clearly label concentration-response plots on the same graph representing the effects of: a. Increasing concentrations of an agonist, A (label A)

b. Increasing concentrations of an agonist, A, in the presence of a fixed concentration of a competitive antagonist, B (label A+B)

c. Increasing concentrations of an agonist in the presence of a fixed concentration of a noncompetitive antagonist, C (label A+C) d. Increasing concentrations of a partial agonist, D (label D), that is MORE POTENT than A. e. Increasing concentrations of a partial agonist, E (label E), that is LESS POTENT than A.

Make sure that the axes are labeled and whether the graphs are linear or log plots.

2. Write the Langmuir equation and use it to explain what fraction of receptors are bound by drug if the drug concentration, D, is equal to the equilibrium dissociation constant, Kd, for the receptor.

3. Explain with words and graphs how a quantal dose response curve is constructed and how this type of analysis is used to determine the therapeutic index of a drug