JEB3 is a rare single gene disorder. The gene responsible for this disorder, LAMA3, maps to...
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JEB3 is a rare single gene disorder. The gene responsible for this disorder, LAMA3, maps to chromosome 18 and encodes laminin-3. Laminin-3 is one of many proteins that anchor cells to the basal lamina. Individuals with JEB3 show blistering and shearing of the skin after minor mechanical trauma. The pedigree below represents a hypothetical family affected with JEB3. Shaded individuals are affected. Please consider how ALL affected individuals might affect your answer. II IV O Ö Ó Ó O 2999 V Individual V-1 marries V-2. What is the probability that their first child will be affected with JEB3? JEB3 is a rare single gene disorder. The gene responsible for this disorder, LAMA3, maps to chromosome 18 and encodes laminin-3. Laminin-3 is one of many proteins that anchor cells to the basal lamina. Individuals with JEB3 show blistering and shearing of the skin after minor mechanical trauma. The pedigree below represents a hypothetical family affected with JEB3. Shaded individuals are affected. Please consider how ALL affected individuals might affect your answer. II IV O Ö Ó Ó O 2999 V Individual V-1 marries V-2. What is the probability that their first child will be affected with JEB3?
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First Part Generation IV IV6 IV8 are affected Assuming JEB3 is recessive IV6 IV8 are must be homozyg... View the full answer
Related Book For
Fundamentals of biochemistry Life at the Molecular Level
ISBN: 978-0470547847
4th edition
Authors: Donald Voet, Judith G. Voet, Charlotte W. Pratt
Posted Date:
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