experiencing withdrawal symptoms when missing a dose. How should this information be interpreted? The patient meets diagnostic criteria for opioid use disorder (OUD) due to the presence of withdrawal symptoms. The patient is at high risk for developing OUD and should be transitioned to non-opioid pain management. The presence of withdrawal symptoms indicates the patient is misusing their prescription and requires immediate intervention. Withdrawal symptoms are expected in patients on long-term opioid therapy and do not confirm OUD. Withdrawal symptoms require tapering or discontinuation of opioid therapy to prevent dependence