Explain in an easy way and function

Natriuretic Peptides: Natri- : means salt (Na+) -uretic : means 'to pee out' The issue: excess salt accumulation Atrial natriuretic peptide (ANP) causes high blood volume and too high STIMULUS of blood pressure... 1 Increased stretch of baroreceptors in atria Detected by overstretching of RECEPTOR CONTROL CENTER 2 Atria respond to 3 Atria release ANP into cardiomyocytes in atria & ventricles of stimuli. the blood. the heart due to higher than normal NET EFFECT venous return & End Diastolic Volume 5 Peripheral resistance decreases blood volume decreases, decreasing blood pressure. ANP ANP The 'stretched' cardiomyocytes release AND ANP ANP hormones > Atrial Natriuretic Peptide ANP AND ANP (ANP, shown) or B-type Natriuretic Blood Peptide (BNP, from ventricles) 4 EFFECTORS: ANP binds to effectors to cause Kidney Net effect on targets: Nat Systemic blood HO vessels - Kidney: increased salt elimination ANP binds in the urine by blocking RAAS... Blood reduces blood volume Vasodilation; Increased glomerular Increased loss of Na* Decreased release of decreases peripheral filtration rate (GFR); and water in urine; renin (and interferes with resistance and increases urine output to decreases blood volume action of angiotensin II); Blood Vessels: general decreases blood decrease blood volume and blood pressure decreased release of pressure and blood pressure aldosteronismd ADH vasodilation.... reduces blood pressure **Clinical: Sodium is very hard to avoid in our modern diets... unfortunately the cardiomyocytes 'desensitize' over time and may fail to release sufficient ANP to sustain a normal, healthy blood pressure