Explain in an easy way Infective Endocarditis Three elements necessary 1 Endocardial damage Valve surgery, valve disease, prosthetic valve Cause heart murmur, abnormal blood flow Damaged valve attracts platelets clots 2 Microorganism enters blood Dental work, IV, IV drug use etc Adheres to damaged valve endocardium 3 Infective vegetations grow on valve Bacteria enter the clot made in step 1 Protected by the fibrin clots from WBC and antibiotics (From Damjanov I, Linder J Pathology a color atlas, St Louis, 2000, Mosby ) Bacteria reproduce, grow, destroy tissue Further damage to valves, spread infection

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Explain in an easy way Infective Endocarditis   Three elements necessary 1  Endocardial damage   Valve surgery, valve disease, prosthetic valve   Cause heart murmur, abnormal blood flow   Damaged valve attracts platelets clots 2  Microorganism enters blood   Dental work, IV, IV drug use etc    Adheres to damaged valve endocardium 3  Infective vegetations grow on valve   Bacteria enter the clot made in step 1   Protected by the fibrin clots from WBC and antibiotics (From Damjanov I, Linder J  Pathology  a color atlas, St Louis, 2000, Mosby )   Bacteria reproduce, grow, destroy tissue   Further damage to valves, spread infection

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Question: Explain in an easy way Infective Endocarditis . Three elements necessary 1. Endocardial damage . Valve surgery, valve disease, prosthetic valve . Cause heart murmur,

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