Explain in brief which scale-up criterion you would use in the following cases of microbial cell growth. (i) Shear sensitive mammalian cells (ii) Highly aerobic prokaryotic cells that have high oxygen demand V A stirred aerated bioreactor is to be scaled down from 10m to 0.1m> where the dimensions of the large tank are Di = 2m, D; = 0.5m/ and operated at impetter speed of = = 100 rpm. (iii) (iv) Determine the dimensions of the small tank/(Dt, Di, H) by using geometric similarity. Estimate the required rotational speeds of the impeller in the small tank if the large reactor is to be scaled down based on constant (P/V) and constant impeller tip speed criterion