Explain

Nonspecific Immunity Complement = plasma proteins activated by cascades of chemical reactions 0) Pathways: Classical Alternative Lectin There are many different complement proteins, and each of these chemical pathways is very specific in terms of which protein/enzyme is activated first through last (this is called a triggered enzyme reaction pathway, where Enzyme 1 activated Enzyme 2 which activates Enzyme 3, etc) Nonspecific Immunity Pathway activation: @) Classical Pathway by antigen-antibody complexes, or by direct binding of the 1 protein in the complement cascade to a pathogen surface This is accomplished by SPRPs (soluble pattern recognition proteins) on the complement proteins that ID non-self or altered self molecules Mannon-Binding Lectin Pathway Lectin (a specific complement protein) bind to a carbohydrate (mannose) on the pathogen membrane Alternative Pathway direct binding of the 1%' protein in the complement cascade to a pathogen surface using SPRPs