• Explain the various pKa values for these derivatives of the naturally occurring amino acid glutamic acid. Say which pKa belongs to which functional group and explain why they vary in the different derivatives.
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HO₂C CO₂H NH₂ glutamic acid: pK,s 2.19, 4.25, and 9.67 H₂NOC CO₂H EtO₂C NH₂ glutamine: pK,s 2.17 and 9.13 EtO₂C CO₂H NH₂ monoethyl ester; pk,s 2.15 and 9.19 CO₂Et NH₂ diethyl ester: pK, 7.04 HO₂C CO₂Et NH₂ monoethyl ester: pk,s 3.85 and 7.84 HO₂C CO₂H NH₂ glutamic acid: pK,s 2.19, 4.25, and 9.67 H₂NOC CO₂H EtO₂C NH₂ glutamine: pK,s 2.17 and 9.13 EtO₂C CO₂H NH₂ monoethyl ester; pk,s 2.15 and 9.19 CO₂Et NH₂ diethyl ester: pK, 7.04 HO₂C CO₂Et NH₂ monoethyl ester: pk,s 3.85 and 7.84

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J H0C 425 3 sto 5 385 N... View the full answer