FIU-PCB3063-Fall19-Prof. Granados-Cifuentes This document is for your individual exclusive use. Sharing it in any way, shape,...

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FIU-PCB3063-Fall19-Prof. Granados-Cifuentes This document is for your individual exclusive use. Sharing it in any way, shape, or form is prohibited. Activity Worksheet GER Eukaryotes Modified from MacMillan IF-AT. Questions and answer choices on the screen. Please note that some questions might be an extension of a question from this worksheet. They will be shown towards the end of the class. 1. Malaria, one of the most pervasive and destructive of all infectious diseases, is caused by protozoan parasites of the genus Plasmodium, which are transmitted from person to person by mosquitoes. Plasmodium parasites are able to evade the host immune system by constantly altering the expression of their var genes, which encode Plasmodium surface antigens (L. H. Freitas-Junior, et al. 2005. Cell 121:25-36). Individual var genes are expressed when chromatin structure is disrupted by chemical changes in histone proteins. What type of chemical changes in the histone proteins might be responsible for these changes in gene expression? Sharing not allowed 2. A geneticist is trying to determine how many genes are found in a 300,000-bp region of DNA. Analysis shows that ten H3K4me3 modifications are found in this piece of DNA. What might their presence suggest there? about the num sensiti emutation at a locus that encodes an 3. In a line of human cells grown in culture, a geneticist isolates a temperature- acetyltransferase enzyme; at temperatures above 38°C the mutant cells produce a nonfunctional form of the enzyme. What would be the most likely effect of this mutation when the cells are grown at testing X31b as a possible drug for treating prostate cancer. 4. X31b is an experimental compound that is taken up by rapidly dividing cells. Research has shown that X31b stimulates the methylation of DNA. Some cancer researchers are Offer a possible explanation for why X31b might interested in be an effective anticancer drug. FIU-PCB3063-Fall19-Prof. Granados-Cifuentes This document is for your individual exclusive use. Sharing it in any way, shape, or form is prohibited. Activity Worksheet GER Eukaryotes Modified from MacMillan IF-AT. Questions and answer choices on the screen. Please note that some questions might be an extension of a question from this worksheet. They will be shown towards the end of the class. 1. Malaria, one of the most pervasive and destructive of all infectious diseases, is caused by protozoan parasites of the genus Plasmodium, which are transmitted from person to person by mosquitoes. Plasmodium parasites are able to evade the host immune system by constantly altering the expression of their var genes, which encode Plasmodium surface antigens (L. H. Freitas-Junior, et al. 2005. Cell 121:25-36). Individual var genes are expressed when chromatin structure is disrupted by chemical changes in histone proteins. What type of chemical changes in the histone proteins might be responsible for these changes in gene expression? Sharing not allowed 2. A geneticist is trying to determine how many genes are found in a 300,000-bp region of DNA. Analysis shows that ten H3K4me3 modifications are found in this piece of DNA. What might their presence suggest there? about the num sensiti emutation at a locus that encodes an 3. In a line of human cells grown in culture, a geneticist isolates a temperature- acetyltransferase enzyme; at temperatures above 38°C the mutant cells produce a nonfunctional form of the enzyme. What would be the most likely effect of this mutation when the cells are grown at testing X31b as a possible drug for treating prostate cancer. 4. X31b is an experimental compound that is taken up by rapidly dividing cells. Research has shown that X31b stimulates the methylation of DNA. Some cancer researchers are Offer a possible explanation for why X31b might interested in be an effective anticancer drug.

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1 Malaria one of the most pervasive and destructive of all infectious diseases is caused by protozoan parasites of the genus Plasmodium which are transmitted from person to person by mosquitoes Plasmo... View the full answer