For each of these conditions describe 1) the normal function of the enzyme/reaction IN DETAIL and 2) how the indicated modification would induce pathology.

1. Biotin without the straight-chain alkyl carboxylic acid in pyruvate carboxylase
2. Hexokinase in the brain mutated to have a Km equal to glucokinase
3. A lack of malate dehydrogenase in the cytosol of hepatocytes
4. Pyruvate kinase that is insensitive to Fructose 1, 6 bisphosphates in muscle
5. Red blood cells that are deficient in  2,3-BPG mutase

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Biotin also known as vitamin B 7 or vitamin H is one of the B vitamins a group of chemically distinct watersoluble vitamins that also includes thiamine riboflavin niacin pantothenic acid pyridoxine fo... View the full answer