For the following, Cycle 1 indicates the cycle where the acetylCoA containing labeled carbon is first added to oxaloacetate. Cycle2 indicates the following cycle. IDH = isocitratedehydrogenase, ????-KGDH = ????-ketoglutarate dehydrogenase, and PDH =pyruvate dehydrogenase.

If acetate was labeled at C1, where would it be lost (throughthe CAC) as CO₂?

If glucose was labeled at C3, where would it be lost asCO₂?

What if glucose was labeled at C5?

Aspartate can be converted into oxaloacetate. If aspartatewith the ????-carboxyl group was labeled, where would the labeledcarbon be lost as CO₂?

Can someone show how you are supposed to derive the answers tothese questions? Thank you.

Answer rating: 100% (QA)

1 If acetate was labeled at C1 where would it be lost through the CAC as CO2 In the Citric Acid Cycle CAC acetate is combined with oxaloacetate to for... View the full answer