The cyclization reaction shown below involves two sequential condensation reactions, and can be catalyzed by either...
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The cyclization reaction shown below involves two sequential condensation reactions, and can be catalyzed by either a strong acid or a strong base.¹ a. Draw the neutral intermediate that would form after the first condensation but before the second condensation in each mechanistic pathway option. acid or R2 base (cat.) aldol condensation NH2 R3 condensation imine R₁ R2 H₂O N R3 2 H₂O H₂O b. Draw the missing starting material for the synthesis of SN-38, using the same cyclization reaction as shown above. HO acid or base (cat.) HO (similar reaction as above) HO SN-38 (cancer treatment) The cyclization reaction shown below involves two sequential condensation reactions, and can be catalyzed by either a strong acid or a strong base.¹ a. Draw the neutral intermediate that would form after the first condensation but before the second condensation in each mechanistic pathway option. acid or R2 base (cat.) aldol condensation NH2 R3 condensation imine R₁ R2 H₂O N R3 2 H₂O H₂O b. Draw the missing starting material for the synthesis of SN-38, using the same cyclization reaction as shown above. HO acid or base (cat.) HO (similar reaction as above) HO SN-38 (cancer treatment)
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Related Book For
Precalculus Concepts Through Functions A Unit Circle Approach To Trigonometry
ISBN: 9780137945139
5th Edition
Authors: Michael Sullivan
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