Question: Genome annotation: Genomes are often annotated by comparing sequences among organisms. How might genome annotations be further enhanced and improved? Computationally determined gene structures like

Genome annotation:

Genomes are often annotated by comparing sequences among organisms. How might genome annotations be further enhanced and improved?

Computationally determined gene structures like introns and exons are often not completely correct. Explain why this is the case. How would you check whether an annotation was correct?

Many predicted genes do not have clear direct counterparts in other organisms. What other features can be used to make predictions regarding gene function?

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