Genome mining is an emerging approach to drug discovery. i. Genome mining involves a combination of genomics,
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Genome mining is an emerging approach to drug discovery.
i. Genome mining involves a combination of genomics, bioinformatics, molecular biology, and analytical chemistry. Briefly outline what takes place at each of these steps in the process.
ii. What are the general features of a pleiotropic approach to activating a silent biosynthetic gene cluster (BGC)? Briefly outline the main advantage and the main disadvantage of such approaches. Give one example of a pleiotropic approach that can be used to activate silent BGCs.
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