Question: Hello, I need help with question 1.9 . The explanation and solution would be great so that I can review and check my answer. Thank
Hello, I need help with question 1.9
. The explanation and solution would be great so that I can review and check my answer. Thank you!
1.7 Now that you have figured out the reaction mechanism, let's explore the action mechanism of the following drug. Notice that this molecule is composed of two chloroethylamine groups and therefore can react with two different nucleophiles. Complete the following reaction mechanism. The above reaction is responsible for the activity of the drug. Because of its ability to react with two nucleophiles, the drug can create a bridge between two biologically active molecules and disrupt their activity. . This process is known as 'cross-linking'. For example, it can react with two DNA strands and prevent their separation during replication. This will cause cytotoxicity and cell death. 1.8 Draw a scheme/cartoon to represent the general idea of chemical cross-linking. 1.9 The reactivity of nitrogen mustards can be tuned by changing the chemical structure. Compare the reactivity of the two molecules below. Which nitrogen is more nucleophilic? Why? Draw a resonance structure to support your reasoning
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