Histone H1 binds two DNA helices.

a) True

b) False

2. The distinct zig-zag appearance of the chromatin fibre is due to ____________

a) Nucleosome

b) Histone H1

c) Histone core

d) Linker DNA

3. With respect to Histone H1 DNA packaging which of the following is false?

a) H1 induce 10 nm fibre formation

b) H1 binding gives nucleosome a defined angle

c) H1 stabilizes higher order chromatin structures

d) H1 binds to two DNA helices at once

4. With respect to the solenoid model of nucleosome, which of the following is true?

a) Helical model

b) 8 nucleosomes per turn

c) Structure supported by X - ray diffraction

d) Helical pitch of approximately 13 nm

5. What marks the difference between the solenoid and the zig-zag models of 30 nm fibres?

a) Linker histone molecule

b) Linker DNA

c) Nucleosome structure

d) 10 nm fibre

6. The histone tails stabilize the 30 nm fibre by interacting with adjacent nucleosomes.

a) True

b) False

7. Which of the following is not a characteristic of the nuclear scaffold?

a) Associated with loops of 40 - 90 kb

b) Topoisomerase I

c) SMC protein

d) Proteinacious in nature

8. Which histone molecule produces novel binding sites for protein components of the kinetochore?

a) CENP - A

b) H2A

c) H3

d) H4

9. With respect to remodeling complex of nucleosome, which of the following is not true?

a) Does not require ATP

b) Favors sliding of histone

c) Favors transfer of histone

d) Favors remodeling of histone