Aspirin, an acetyl derivative of salicylic acid, is a white, crystalline, weakly acidic substance, with a...
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Aspirin, an acetyl derivative of salicylic acid, is a white, crystalline, weakly acidic substance, with a melting point of 136 "C (277 F), and a boiling point of 140 °C (284 °F).24 Its acid dissociation constant (pK.) is 3.5 at 25 °C (77 °F) (0) With reference to electron withdrawing and releasing group effects explain why Aspirin is stronger acid than Acetaminophen. (3marks) Acetaminophen undergoes reduction reaction to give product A. Illustrate the (I) complete reaction including the reagent and condition involved. (3marks) Aspirin reacts with Grignard reagent CH3M9B to give Structure 'B'. Show the (ii) formation of structure B. (3marks) Using chemical equation give the formation of product when p-Hudroxwaniline (2 marks) (iv) reacts with bromine. HO. Acetic anhydride Salicylic acid (o-Hydroxybenzole acid) CH Aspirin (an ester) H. NH + CH,COCCH, %3D + CH,CO- NAOH H20 Acetic HO CH3 p-Hydroxyaniline anhydride Acetaminophen 2004 ThonaNos Cole Aspirin, an acetyl derivative of salicylic acid, is a white, crystalline, weakly acidic substance, with a melting point of 136 "C (277 F), and a boiling point of 140 °C (284 °F).24 Its acid dissociation constant (pK.) is 3.5 at 25 °C (77 °F) (0) With reference to electron withdrawing and releasing group effects explain why Aspirin is stronger acid than Acetaminophen. (3marks) Acetaminophen undergoes reduction reaction to give product A. Illustrate the (I) complete reaction including the reagent and condition involved. (3marks) Aspirin reacts with Grignard reagent CH3M9B to give Structure 'B'. Show the (ii) formation of structure B. (3marks) Using chemical equation give the formation of product when p-Hudroxwaniline (2 marks) (iv) reacts with bromine. HO. Acetic anhydride Salicylic acid (o-Hydroxybenzole acid) CH Aspirin (an ester) H. NH + CH,COCCH, %3D + CH,CO- NAOH H20 Acetic HO CH3 p-Hydroxyaniline anhydride Acetaminophen 2004 ThonaNos Cole
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Related Book For
Chemistry The Central Science
ISBN: 978-0321696724
12th edition
Authors: Theodore Brown, Eugene LeMay, Bruce Bursten, Catherine Murphy, Patrick Woodward
Posted Date:
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