How do mitochondrial defects and dysfunction contribute to the pathogenesis of mitochondrial diseases, such as mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes (MELAS), and what are the current strategies for diagnosing and treating these complex disorders? 

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Mitochondrial diseases are a group of genetic disorders that are caused by mutations in mitochondrial DNA or nuclear DNA leading to defects in the mit... View the full answer