Question: How does a BLAST search work? Put the steps in order. Attempt every possible global alignment, calculate p - values for each alignment, select the

How does a BLAST search work? Put the steps in order.
Attempt every possible global alignment, calculate p -values for each alignment, select the alignment with the lowest chance of type 1
statistical error (false positive).
Split a sequence into words, find improbable local alignments to a database using a scoring matrix, extend words to make HSP's,
calculate e-values, discard matches over the threshold.
Add enough gaps to make every nucleotide or amino acid line up with a sequence from the database, iterate the process, construct a
neighbor-joining family tree, report results below the e-value threshold.
Like google - use several smaller computers or CPU threads to run searches over small datasets, aggregate the results, and rank
results according to a proprietary algorithm.
Spilit a sequence into words, use a scoring matrix to calculate the probability of each word randomly appearing, report the matches
with e-values below the threshold.
How does a BLAST search work? Put the steps in

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