Question: How does a BLAST search work? Put the steps in order. Attempt every possible global alignment, calculate p - values for each alignment, select the
How does a BLAST search work? Put the steps in order.
Attempt every possible global alignment, calculate p values for each alignment, select the alignment with the lowest chance of type
statistical error false positive
Split a sequence into words, find improbable local alignments to a database using a scoring matrix, extend words to make HSPs
calculate evalues, discard matches over the threshold.
Add enough gaps to make every nucleotide or amino acid line up with a sequence from the database, iterate the process, construct a
neighborjoining family tree, report results below the evalue threshold.
Like google use several smaller computers or CPU threads to run searches over small datasets, aggregate the results, and rank
results according to a proprietary algorithm.
Spilit a sequence into words, use a scoring matrix to calculate the probability of each word randomly appearing, report the matches
with evalues below the threshold.
Step by Step Solution
There are 3 Steps involved in it
1 Expert Approved Answer
Step: 1 Unlock
Question Has Been Solved by an Expert!
Get step-by-step solutions from verified subject matter experts
Step: 2 Unlock
Step: 3 Unlock
