How to interpret this data about limit of detection and limit of quantification for pure drug solution
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How to interpret this data about limit of detection and limit of quantification for pure drug solution and drug suspension analysed by HPLC.
HPLC conditions - mobile phase 0.1 % TFA:ACN in 55:45 v/v ratio. C18 5µm column, flow rate 1mL/min, injection volume 10 µL and UV detection is 240nm.
concentration of drug samples to measure LOD/LOQ were: 20, 15, 10, 8, 6, 4, 2 µg/mL
all samples were prepared in methanol
pure drug solution
- LOD = 0.278 µg/mL
-LOQ = 0.843 µg/mL
drug suspension
- LOD = 3.347 µg/mL
-LOQ = 1.104 µg/mL
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