how to respond tot his discussion The differences between a research hypothesis and null hypothesis is that the research hypothesis is something that the researcher is trying to prove. On the other hand, a null hypothesis is something that the researcher is trying to disprove. Another difference is that a research hypothesis has to variables and a null hypothesis can only be rejected by the research. Both are used in research and are both needed. Another difference is that the null hypothesis has no correlation between the two variables in the research hypothesis