I need some help with this question?

The drop down options are 1st one: (less than/greater than), 2nd one: ( do not reject Ho, reject Ho), 3rd one: (insufficient/sufficient)

Patient Before After 175 270 215 225 250 166 YOUDON- 365 258 393 272 439 207 449 311Increased blood vessel formulation is a predictive factor in survival for a certain disease. One treatment is stem cell transplantation with the patient's own stem cells. The accompanying data table represents the microvessel density for patients who had a complete response to the stem cell transplant. The measurements were taken immediately prior to the stem cell transplant and at the time the complete response was determined. Complete parts (a) through (d). Click the icon to view the data table. a. At the 0.01 level of significance, is there evidence that the mean microvessel density is higher before the stem cell transplant than after the stem cell transplant? Let u be the mean density before the transplant and let u2 be the mean density after the transplant. State the null and alternative hypotheses. Choose the correct answer below. O A. Ho: HD = 0 (where HD = H1 - H2) O B. Ho: HD = 0 (where HD = H1 - H2) H1: HD > 0 H1 : HD * 0 O C. Ho: HD 20 (where HD = M1 - H2) OD. Ho: HD # 0 (where HD = M1 / H2) H1 : HD 0 H1 : HD >0 The test statistic =. (Round to two decimal places as needed.) The p-value is. (Round to three decimal places as needed.) Since the p-value is the value of a, There is evidence to conclude that the mean microvessel density is higher before the stem cell transplant than after the stem cell transplant. b. Interpret the meaning of the p-value in (a). Choose the correct answer below. O A. The p-value is the probability of not rejecting the null hypothesis when it is false. O B. The p-value is the probability of obtaining a sample mean difference of 82.43 or more if the population mean densities both before and after the transplant are different. O C. The p-value is the probability of obtaining a sample mean difference of 82.43 or more if the population mean densities both before and after the transplant are the same.d. What assumption is necessary about the population distribution in order to perform the test in (a)? O A. It must be assumed that the distribution of the differences between the measurements is skewed. O B. It must be assumed that the distribution of the differences between the measurements is approximately normal. 0 C. It must be assumed that the distribution of the differences between the measurements is approximately uniform