Question: I would please like an explanation on this problem, possibly steps to help me understand as well. Thank you The sequence below depicts a hydroboration/oxidation
I would please like an explanation on this problem, possibly steps to help me understand as well. Thank youThe sequence below depicts a hydroboration/oxidation reaction sequence of the cholesterol analogue 1 using 9-BBN as the hydroborating agent. This reaction sequence led to the expected alcohol 2a alongside traces of an unexpected isomer 2b. A series of experiments revealed that the proportion of isomer 2b increased as the temperature of the hydroboration step was increased from -40 C to 100 C. 1. 9-BBN 2. H2O/NaOH/H2O2 HO HO " A OH OH 2a 2b Suggest using curved arrow mechanisms how the unexpected isomer 2b might be formed and explain why increasing the temperature of the hydroboration step leads to more of this unusual isomer being formed
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