Question: In regards to the mRNA sequence shown in the first question, suppose a mutation occurred at position 1 1 that changed the cytosine to an
In regards to the mRNA sequence shown in the first question, suppose a mutation occurred at position that changed the cytosine to an adenine. What effect would this have on the translated protein?
The protein would be shorter.
It would constitute a nonsynonymous substitution.
It would alter the reading frame.
It would not affect the sequence of the translated protein.
Shown below is a portion of a eukaryotic mRNA that encodes a protein. The sequence is continuous and is shown in nucleotide chunks to make it easier to visualize. The numbers on the left indicate the relative locations of nucleotides in the sequence, starting with position at the end of the mRNA strand. The gene that encodes this protein contains introns, but they have already been completely spliced from this transcript. The stop codon is shown in bold and underlined.
cgucucuccu cgcuaagaau cccucaguua aacaagaacu gcaugggacu
ugcaggucug ccggcuuccu gccugaggag ugcaaaggac augaaacauc
ggcugggguu ccugcugcag aagucagauu ccugcgaaca caguucuuca
cacagcaaga aggacaaagu aguaacuugc cagaggguaa gccaagaaga
agucaagaaa ugggcugaau cgunggaaaa ccugauncac caugaaugug
gacuggcagc uuucaaagcu uuccugaagu cggaauacag cgaggagaac
aungacuucu ggaucagcug cgaggaguac aagaagauca agucaccuuc
uaaacuaagu cccaaagcca agaagaucua caacgaguuc aucucagugc
aagcaacaaa agaggugaac cuggacucuu gcaccagaga ggagacaagc
cggaacaugu uacagcccac aauaaccugu uuugaugaag cccagaagaa
gauuuucaac cugauggaaa aggauuccua ccgccgcuuc cucaagucuc
gauncuaucu ugaccugacc aauccuucca gcugcggggc agagaagcag
aaaggagcca agaguucugc agacugcacu ucccuggucu cccagugugc
cuaauucuca cacagaggca gggagcccaa augccaagac ucuaugcucu
gaaaaaccug aggccaaaua ungaucuuaa gcaccaaugc uuuauccaca
unguagccua guguccaugc ugccugccgc gugugaguca cuuccaugua
aaacuagccu uaguuguggu guugggguuu ucacuagggu aagacccaau
uuguuuuaaa uuuucccaag ucuccuuaag
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