In Severe Combined Immunodeficiency disease, where there are no functioning lymphocytes, which of the following key step(s) in the inflammation process is/are NOT working in a person with this condition?

1.Tight junctions between endothelial cells are disrupted, allowing fluid to leak from the vessels into the tissue.

2. The phagocytes bind to the endothelial cells and exit the blood vessel by a process called diapedesis.

3. Once in the tissues, phagocytic cells engulf and destroy any microbial invaders.

4.The increase of fluids in the tissues causes the swelling and pain associated with inflammation.

5. The diameter of local blood vessels increases due to the action of inflammatory mediators.

Group of answer choices

A, 1

B, 2

C, 3

D, 1 and 2

E, 2, 3, and 5

F, none of the choices are correct

2, Identify the role(s) of natural killer cells.

A, Phagocytosis of virus infected cells AND production of cytokines that help regulate and direct certain immune responses.

B, Antibody-dependent cellular cytotoxicity AND destruction of macrophages that recognize normal "self" molecules

C, Destruction of stressed host cells which lack MHC Class I receptors (such as those infected with viruses or cancer cells) AND antibody-dependent cellular cytotoxicity in host cells

D, Antibody-dependent cellular cytotoxicity in host cells and cells that produce MHC Class 1 and MHC Class 2 receptors

E, Regulation and direction of certain immune responses AND phagocytosis of virus infected cells AND stimulation of MHC class I molecules.

3, Penicillin-binding proteins

a, primarily function in the cell to bind to beta-lactam drugs.

b, are enzymes.

c, are involved in cell wall synthesis.

d, inhibit non-growing bacteria.

e, are enzymes AND are involved in cell wall synthesis.