Which of the following statements BEST describes the mechanism of action of penicillin? Penicillin acts as...

 

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Which of the following statements BEST describes the mechanism of action of penicillin? Penicillin acts as a mimetic of the D-Ala-D-Ala moiety of the normal substrate, and binds the active site of the transpeptidase enzyme leading to irreversible inhibition of the enzyme and inhibition of cell wall synthesis. The binding of the B-lactam ring of penicillin to a transpeptidase enzyme stabilises the enzyme and leads to increased cross-linking between glycine residues. The binding of the B-lactam ring of penicillin to the transpeptidase enzyme, stimulates cross linking activity and results in a cell wall that is impermeable to antibiotics. Penicillin inhibits the transpeptidation enzymes that stabilise ribosomal structure and thus, interferes directly with protein synthesis. Which of the following statements BEST describes the mechanism of action of penicillin? Penicillin acts as a mimetic of the D-Ala-D-Ala moiety of the normal substrate, and binds the active site of the transpeptidase enzyme leading to irreversible inhibition of the enzyme and inhibition of cell wall synthesis. The binding of the B-lactam ring of penicillin to a transpeptidase enzyme stabilises the enzyme and leads to increased cross-linking between glycine residues. The binding of the B-lactam ring of penicillin to the transpeptidase enzyme, stimulates cross linking activity and results in a cell wall that is impermeable to antibiotics. Penicillin inhibits the transpeptidation enzymes that stabilise ribosomal structure and thus, interferes directly with protein synthesis.

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Option C Penicillin kills bacteria through binding of the betalactam ring to DDtranspeptidase ... View the full answer