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Final Exam

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Hint

Question $45$ of $50$

Cancer is characterized by uncontrolled cell division. Cell division is preceded by DNA replication. Several proteins of the DNA$-$replication machinery can be targets for chemotherapeutic agents. One such protein is topoisomerase.

Select the effects that result from any degree of inhibition of topoisomerase.

The double helix is not unwound, halting DNA replication.

The double helix reanneals to its natural state, stopping DNA replication.

Supercoils accumulate, resulting in chromosomal instability.

Single$-$stranded breaks form, leading to DNA fragmentation.

The RNA primer is not synthesized, preventing initiation of replication.