Question: LDL binds with cell surface receptor and gets internalized via clathrinmediated endocytosis. This process helps in maintaining the cholesterol-LDL level in the plasma. However,

LDL binds with cell surface receptor and gets internalized via clathrinmediated endocytosis.

LDL binds with cell surface receptor and gets internalized via clathrinmediated endocytosis. This process helps in maintaining the cholesterol-LDL level in the plasma. However, in a disease known as familial hypercholesterolemia (FH), very high levels of plasma cholesterol is found. This could be due to mutation in which one of the following genes in FH patients? (A) Clathrin (B) LDL (C)LDL receptor (D)Adaptor

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