lets work on this problem

12. Small GTPases are GTP binding proteins that control a large number of events. Under which of the following conditions is a GTPase active so that it can transmit a signal to downstream factors? a. When the GAP of the small GTPase is active b. When the GEF of the small GTPase is inhibited c. When a dominant negative form of the small GTPases is expressed d. When the GAP of the small GTPase is inhibited e. When the effector is activating the GEF