Many phase I studies now include adaptive study designs which allow changes to the design of the trial as new information is discovered; as is often the case with phase I studies. According to the author, adaptive trial designs have many benefits, including:

Adaptive trial designs enable subjects to participate in multiple trials at once.

This type of trial design may be used internationally.

This type of trial design will assess the maximum tolerated single dose.

More efficient and thorough late phase multicenter research related to dose selection, subject selection, and safety monitoring.