Question: Metabolic control analysis, direct method (10 points). Given the following two-step pathway: where E 1 and E 2 represent the enzymes for the first and

Metabolic control analysis, direct method (10 points). Given the following two-step pathway:

Metabolic control analysis, direct method (10 points). Given the following two-step pathway:

where E1 and E2 represent the enzymes for the first and second reactions, respectively.

The steady-state flux (J, in units of mM/h) can be described as:

(8) Calculate the flux control coefficients ( ) for this system when E1=15mM.

(2) Using your result from Part a, what is the sum of ? Is this result expected? Why or why not?

E1E2SX1P E1E2SX1P

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