Metabolic pathways resemble assembly lines. The pathwayA$$B$$C$$D$$EA$$B$$C$$D$$E uses four enzymes to convert substrate AA to final product EE$.$ In Blank, the final product EE downregulates the first enzyme of the pathway.target $1$ of $7$

In Blank, the concentrations of substrates and products regulate the enzyme as a consequence of the law of mass action.target $2$ of $7$

Pyruvate kinase is allosterically activated by fructose$-1,6-$bisphosphate. This is an example of Blank.target $3$ of $7$

The downregulation of phosphofructokinase by citrate is an example of Blank.target $4$ of $7$

A$($an$)$ Blank results when a change in activity at an active site is caused by the interaction of an effector molecule at a site other than the active site.target $5$ of $7$

Hexokinase, the first step in glycolysis, is inhibited by high concentrations of glucose$-6-$phosphate. This is an example of Blank.target $6$ of $7$

Blank is when the product of an enzyme earlier in a pathway activates a later enzyme in the same pathway.