Multiple Drug Dosing One compartment, IV bolus, first order elimination, open model (Questions 1-10)

1 If Cmax1 = 7.5 mg/L, and the dosing interval (=6hrs) and the rate constant of elimination is 0.1 hr-1 what is the value of Cmin1?

2 Question#2 If Cmax1 = 7.5 mg/L, and the dosing interval (=6hrs) and the rate constant of elimination is 0.1 hr-1 what is the value of Cmax2?

Question#3 If Cmax1 = 7.5 mg/L, and the dosing interval (=6hrs) and the rate constant of elimination is 0.1 hr-1 what the value of Cmin2?

Question#4 If Cmax1 = 7.5 mg/L, and the dosing interval (=6hrs) and the rate constant of elimination is 0.1 hr-1 what is the value of Cmax3?

Question#5 If the dose administered at each time interval is 337.5 mg and the volume of distribution is 45 L or Cmax1 = 7.5 mg/L, and the dosing interval (=6hrs) and the rate constant of elimination is 0.1 hr-1 what is the value of steady state peak concentration (Cpeak, ss)

Question#6 If the dose administered at each time interval is 337.5 mg and the volume of distribution is 45 L or Cmax1 = 7.5 mg/L, and the dosing interval (=6hrs) and the rate constant of elimination is 0.1 hr-1 what is the value of steady state trough concentration (Ctrough, ss)

Question#7 If the dose administered at each time interval is 337.5 mg and the volume of distribution is 45 L or Cmax1 = 7.5 mg/L, and the dosing interval (=6hrs) and the rate constant of elimination is 0.1 hr-1 what is the value of steady state average concentration (Cavg, ss)

Question#8, Calculate the half-life (t1/2) if the rate constant of elimination is 0.1 hr-1. Note One compartment, open model first order of elimination. Round to the nearest hundredth.

Question#9 Calculate the accumulation ratio using the following equation. . = 1.441/2 with =6hrs (the dosing interval) Round to the nearest hundredth.

Question#10 Based on the accumulation ratio, to, to what percent of the total amount of drug in the body each dose contributes to? Please write your answer in percent notation.

This case applies to questions 11-16

A patient is to be started on a continuous infusion of a drug. The information provided about the drug. The rate constant of infusion is ka= 18 mg/hr and the clearance is 1.2 L/hr. The rate constant of elimination k=0.058 hr-1

Question#11 Calculate the steady stade concentration (Css) in mg/L.

Question#12. Calcualte the number of half-life to reach 97% of the study state concentration.

Question#13 Calculate the half life if th e rate constant of elimination is k=0.058 hr-1 . ( Note one compartment, first order elimiantion, open model). Round to the nearest whole number.

Question#14 How many days until 97% of the study state concentration is achieved based on the response of question#13? Round to the nearest tenth.

Question#15 calculate the volume of distribution. Round to the nearest whole number .

Question#16 if a loading dose is desired, what XLD is needed?