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Question 3 (Unit 11} 5 marks Osteoporosis is a common, chronic condition that weakens bones, making them fragile and more likely to break. It develops slowly over several years and is often only diagnosed when a fall or sudden impact causes a bone to break. Drugs do not cure osteoporosis, but they may reduce the symptoms or slow down the progress of the disease. A medical research team wishes to compare the efcacy of two drugs, B1 and B2, that can be used to temporarily alleviate symptoms. It is known that these two treatments will alleviate symptoms only whilst the drug is being taken. Consider the two designs below in turn. Explain how each of the two designs could be implemented in this context. Finally, state which design you would recommend, justifying your choice. Your answer should discuss any pros and cons (if there are any) for each type of trial in this context. 0 A matched-pairs design 0 A crossover design [5]