need help with these questions. will thumbs up!

1. Explain the pathways a protein must take to conformationally fold including the process of folding funnel? 2. What is the function and mechanism of protein disulfide isomerase during protein folding? 3. What are the molecular chaperones? Describe the various heat shock proteins and their function? 4. Explain the reaction mechanism of GroEL/ES assisting in conformational changes and protein folding for a protein? 5. Describe prion proteins with its structural changes and the diseases caused both in animals and humans