newborn boy born to a $48-$year$-$old woman is referred to your clinic. He has a flat face, wide$-$set eyes, epicanthal folds. Upon further investigation, you found that the newborn boy also has esophageal atresia, and some congenital heart defects. You suspect that the patient has Down syndrome.Which of the following genotypes matches the palient's diseasc irisomy $13,$ karyotype is $46,$ XY$,+18$ Trisomy $13,$ karyotype is $47,$ XX$,+13$ Trisomy $21,$ karyotype is $47,$ XY$,+21$ Trisomy $21,$ karyotype is $47,$ XX$,+21$