Question: Now solve on your own the nonlinear data presented on the ADME tab. This abbreviation stands for absorption-distribution-metabolism-elimination and refers to the kinetics of drug

Now solve on your own the nonlinear data presented on the ADME tab. This abbreviation stands for absorption-distribution-metabolism-elimination and refers to the kinetics of drug metabolism. The concentration of drugs in the blood can be found from the following equation in excel where C(t)= concentration of the drug at time t ,C0 = dose, k1 and k 2are rate contants, and = time in minutes. Find the values of C0,k1 and k2.

Now solve on your own the nonlinear data presented on the ADME

please show me how to go about this because I do not know how to do much on excel. Thank you!!!

t (min) 0 12 Conc (ppm) 0.00 18.17 25.97 33.55 31.64 33.33 29.65 22.90 22.72 16.92 13.07 10.32 10.46 8.07 5.92 Find the values of Co and the rate constants, k1 and k2, from the tabluated data 36 48 60 72 84 96 108 I suggest intitial values of Co 50, k10.05, k2 0.01 Drug Metabolism 132 144 168 180 192 204 216 40.00 35.00 30.00 25.00 .6120.00 3.17 15.00 10.00 5.00 0.00 5.048 Series1 2.76 1.98 1.52 240 100 150 200 250 300 time (min) t (min) 0 12 Conc (ppm) 0.00 18.17 25.97 33.55 31.64 33.33 29.65 22.90 22.72 16.92 13.07 10.32 10.46 8.07 5.92 Find the values of Co and the rate constants, k1 and k2, from the tabluated data 36 48 60 72 84 96 108 I suggest intitial values of Co 50, k10.05, k2 0.01 Drug Metabolism 132 144 168 180 192 204 216 40.00 35.00 30.00 25.00 .6120.00 3.17 15.00 10.00 5.00 0.00 5.048 Series1 2.76 1.98 1.52 240 100 150 200 250 300 time (min)

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