One of the most common statistical tests using in nursing research is the independent samples t-test. This test can be used when comparing two independent groups on a continuous dependent variable. Just as the name of the test suggests, the groups must be independent with different participants in each group and the dependent variable must be continuous. The researcher asks whether there is a significant difference in the mean depression scores for both the employed and unemployed caregivers. The depended variable is depression scores. However differences are witnessed in mean depression scores of employed caregivers. For instance, the mean depression scores can be represented as (M=13.42, SD=10.3) and the unemployed caregivers( M=19.61, SD=10.3) having a value of t(108) =3.53, p=0.07. Therefore , the significant (p-value ) of 0.007 show the difference in the mean depressions scores between the employed and unemployed caregivers is statistically significant