ONLY ANSWER PART (ii)and (iv) and (v) Please answer properly and fully for good ratting

(iii) Propose a workplan that can be used to identify the pharmacophore for 1 (no need to include synthetic detail). (10 marks) (iv) Predict the biological activity for 2 where R=OMe,Br, and NO2.(5 marks) (v) Structure 3 was identified as the new lead from 3-D QSAR studies. Unfortunately, compound 3 suffered from poor water solubility. Propose a prodrug for 3 that will have enhanced water solubility, include a synthesis for your proposed prodrug and explain how the lead will be released in vivo. (15 marks) (i) A new protein was identified that appears to be abundant in individuals prone to a certain type of cancer and you are trying to identify a molecule that will bind to this protein as a new lead compound. However, you do not know the structure or the function of the protein. How would you proceed? (20 marks) (ii) The following compound 1 shows anticancer activity through Tankyrase inhibition. Further work led to the development of a 1-D QSAR equation for structure 2 shown below. 1 2 log1/C=0.398+1.089+4.541 3