Patients in shock experience decreased delivery of 02 to tissues, decreased activity of the pyruvate dehydrogenase...
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Patients in shock experience decreased delivery of 02 to tissues, decreased activity of the pyruvate dehydrogenase complex, and increased anaerobic metabolism. Excess pyruvate is converted to lactate, which accumulates in tissues and in the blood, causing lactic acidosis. (a) Since 02 is not a reactant or product of the citric acid cycle, why do low levels of 02 decrease the activity of the pyruvate dehydrogenase complex? (b) To alleviate lactic acidosis, shock patients are sometimes given dichloroacetate, which inhibits pyruvate dehydrogenase kinase. How does this treatment affect the activity of the pyruvate dehydrogenase complex? Patients in shock experience decreased delivery of 02 to tissues, decreased activity of the pyruvate dehydrogenase complex, and increased anaerobic metabolism. Excess pyruvate is converted to lactate, which accumulates in tissues and in the blood, causing lactic acidosis. (a) Since 02 is not a reactant or product of the citric acid cycle, why do low levels of 02 decrease the activity of the pyruvate dehydrogenase complex? (b) To alleviate lactic acidosis, shock patients are sometimes given dichloroacetate, which inhibits pyruvate dehydrogenase kinase. How does this treatment affect the activity of the pyruvate dehydrogenase complex?
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a Low levels of oxygen will inhibit the electron transport chain as ... View the full answer
Related Book For
Fundamentals of biochemistry Life at the Molecular Level
ISBN: 978-0470547847
4th edition
Authors: Donald Voet, Judith G. Voet, Charlotte W. Pratt
Posted Date:
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