Pharmacokinetics (Short answer and multiple choice questions)

*Please only answer the questions if you know the topic thoroughly*

PLEASE SHOW ALL WORK AND ROUND TO 3 SIG FIGS

Ketoprofen is a nonsteroidal anti-inflammatory drug known to displace Mirandopril from its plasma protein binding sites (increases fu by a factor of 2).

1) What is the expected Vd in a patient if ketoprofen was also given (assume a blood volume of 5 L)? The Vd of Mirandopril in healthy volunteers is 11 L. Provide to 3 significant figures.

2) If a patient was begun on an iv infusion of Mirandopril while taking ketoprofen, what would be the approximate time needed to reach steady-state concentrations (90%), in hours? Provide to 3 significant figures.

3) In healthy volunteers, a 90 mg dose of Mirandopril gave an AUC of 13.5 mg x h/L. If an average subject was also given ketoprofen with 90 mg Mirandopril, what would be the approximate AUC of Mirandopril as measured by a standard assay method (total drug concentrations)?

3.4 mg x h/L

6.75 mg x h/L

13.5 mg x h/L

27 mg x h/L

54 mg x h/L

4) In order to obtain the same level of drug effect as 90 mg qd without ketoprofen, what Mirandopril dose should be given in the presence of ketoprofen?

45 mg qd

90 mg qd

180 mg qd