Question: Please answer the question and show r formulas Consider a genetic association study with 250 individuals, where some of them have a given disease (i.e.

Please answer the question and show r formulas

Consider a genetic association study with 250 individuals, where some of them have a given disease (i.e. "cases") and the rest do not (i.e. "controls"). Let A and a denote the major and minor allele respectively. There are three possible genotypes for each individual: AA, Aa and aa. Researchers observe that 20% of the individuals with genotype aa have the disease compared to 10% of the rest (AA/A=). a. Please fill up the missing entries (?) below and show your calculations. genotype control case AA/Aa ? ? ?7 aa 10 b. Please analyze this table at 1% significance level, using related formulas from the textbook. c. Please use an R built-in function to verify your results in Part b, and show your R codes and related output

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