Please help, I think i know a but i really cant think of why liver UPTAKE would be increased.

b. Glucokinase activators are small molecules that allosterically activate glucokinase found in both liver and pancreatic 13 cells. Work published by Grimsby and coworkers showed that these activators worked by increasing both the affinity of the enzyme for glucose as well as the Vmax 11. If a molecule were designed that increased only one of these kinetic parameters, would that molecule have the potential to be as effective as a drug as the ones described by Grimsby et al.? Explain your reasoning. In several rodent models of type 2 diabetes mellitus, glucokinase activators lowered blood glucose levels and increased hepatic (liver) glucose uptake. Provide a biochemical explanation for each of these observations.