Question: Please I need a correct answer because it is important Assignments Below, a scheme for the synthesis of series of compounds with antimicrobial and anticancer
Assignments Below, a scheme for the synthesis of series of compounds with antimicrobial and anticancer activity is shown (from S. K. Sharma, P. Kumar, B. Narasimhan, K. Ramasamy, V. Mani, R. K. Mishra, A. B. A. Majeed Eur. J. Med. Chem. 2012, 16, 16-25). 1. Re-draw the scheme above in an esthetically more attractive way (e.g., use reasonable bond angles, "standard" orientations of the indole moiety and other structural frameworks, correct Rn to Rn, introduce complete numbering, and utilize the available space). Draw the scheme for compounds with R1R5=H and R1R5= Me only, and combine the respective two intermediates in the last step with urea and thiourea ( X=0 and X=S ). 2. Draw in a separate scheme the mechanism of the amide formation (second step of the synthesis)
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