Please locate this reference in a library collection or through a database: Cavazzana-Calvo and Fischer. "Gene therapy for severe combined immunodeficiency: are we there yet?" J Clin Invest. 2007; 117(6): 1456-1465, doi: 10.1172/JCI30953

answer theSE questions.

1. Major successes have been seen with the use of gene therapy to treat SCID, a genetic disease involving the immune system. Summarize the success described in this article as well as current reports worldwide by conducting additional research.

2. Summarize the process of gene therapy based on the information in this article.

3. List and discuss some of the limitations of gene therapy to treat genetic disease.

4. Is gene therapy a potential approach for curing Nicholas's condition? Defend your answer using clear explanations of gene therapy, how it works, and how it might be applied to his specific genetic defect.