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Question 5: 3 Marks The solubility of an active pharmaceutical ingredient at 5 C, 10 C, 20 C, 30 C, 40 C, 50 C is equal to 2.5, 10, 40, 90, 160, and 250 g/L respectively. The density of the solvent is 786 g/L. Now, we need to perform two crystal growth experiments, the first experiment at 5 C and the second experiment at 10 C. Furthermore, we need to perform both of these experiments in a 20 mL jacketed reactor. For both experiments, assume the initial supersaturation ratio, S is 4.68. Assume that for experiment 1, the seed loading is 30% and for the experiment 2, the seed loading is 35%. (a) Calculate the mass of API that we need to add in the crystalliser to create the required level of supersaturation. (6) Calculate the mass of solvent that we need to add. (c) Calculate the seed mass for both experiment1 and 2. (a) Finally, explain how you will perform these experiments in the lab (just explain how will you design these experiments). (e) How will you ensure that, during the experiment only growth occurs in the reactor (i.e., no nucleation)? (n) What are the factors that comes to your mind that could alter the crystal growth kinetics? Hint: Carefully check the solubility data before you answer this question. Question 5: 3 Marks The solubility of an active pharmaceutical ingredient at 5 C, 10 C, 20 C, 30 C, 40 C, 50 C is equal to 2.5, 10, 40, 90, 160, and 250 g/L respectively. The density of the solvent is 786 g/L. Now, we need to perform two crystal growth experiments, the first experiment at 5 C and the second experiment at 10 C. Furthermore, we need to perform both of these experiments in a 20 mL jacketed reactor. For both experiments, assume the initial supersaturation ratio, S is 4.68. Assume that for experiment 1, the seed loading is 30% and for the experiment 2, the seed loading is 35%. (a) Calculate the mass of API that we need to add in the crystalliser to create the required level of supersaturation. (6) Calculate the mass of solvent that we need to add. (c) Calculate the seed mass for both experiment1 and 2. (a) Finally, explain how you will perform these experiments in the lab (just explain how will you design these experiments). (e) How will you ensure that, during the experiment only growth occurs in the reactor (i.e., no nucleation)? (n) What are the factors that comes to your mind that could alter the crystal growth kinetics? Hint: Carefully check the solubility data before you answer this